Best Strains for Arthritis

With the increasing variety of cannabis strains available today, patients have a range of options to explore. Each is unique, offering a combination of cannabinoids and terpenes that contribute to their specific effects. 

These identifiers and effects help patients navigate the extensive selection, especially when identifying the best cultivars for ailments like arthritis. 

So, what are the best strains for arthritis? The answer may vary by patient; however, below are a few valuable tips to help you narrow down the most suitable option.

Can Weed Help with Arthritis?

Current research suggests that cannabis may offer noteworthy benefits for patients with arthritis, and anecdotal reports suggest the same. In fact, a NuggMD survey highlighted that some patients prefer cannabis over traditional pain medicine for neuropathic pain, which is common in patients with arthritis. This may be due to cannabinoids like THC and CBD having anti-inflammatory and pain-reducing effects.¹

In one review, a group of researchers examined Sativex, an oromucosal spray with equal parts THC and CBD. Over the five-week study, the medication improved resting pain, movement, and sleep quality in patients with rheumatoid arthritis (RA), highlighting the two cannabinoids' potential to manage arthritis symptoms.²

The impact of cannabis on chronic pain has been evaluated in various clinical trials. One study found that THC extracts were most effective for pain when administered sublingually (under the tongue). The results came with only mild side effects. This helps support the notion that cannabis treatments may provide relief for arthritis patients. 

A more clinical survey observed that hybrid strains are the most preferred across pain groups. However, strains typically labeled indica may be favored specifically by arthritis patients. The preference may be because of THC's anti-inflammatory effects. THC may be 20 times more effective than aspirin and twice as effective as hydrocortisone for inflammation.³

Further research explores the effects of THC on rheumatoid arthritis (RA), noting that the cannabinoid interacts with specific receptors that make it a potential treatment for RA therapy. That's because THC may address several symptoms of RA, including depression, sleep disturbances, and pain, by influencing the sympathetic nervous system to deliver relief with a low risk of side effects.⁴

It's important to note that individual responses can vary. Still, some research and anecdotal evidence suggest that cannabis could be a valuable option for managing arthritis and improving patient’s quality of life.

Which Terpenes Help With Arthritis?

Instead of battling whether indica vs. sativa for arthritis is best, focus instead on the terpenes in each strain. Some terpenes, common in cannabis, have potential benefits, including anti-inflammatory and pain-relieving properties that can help manage arthritis symptoms. 

Often, the best strains for arthritis will feature one or several of these terpenes.

• Alpha-pinene may show anti-osteoarthritic activity. It's commonly found in some cannabis strains, as well as basil and dill. It may help reduce inflammation and even slow some arthritic progression.³ 
• Myrcene is often found in tropical fruits and strains like Mango Kush. It has anti-inflammatory and pain-reducing effects that can help arthritis patients with muscle relaxation, promoting better sleep.³
• Limonene has antioxidant properties that may protect joint health.⁵
• Camphene and bisabolol are two terpenes that may inhibit inflammatory and neuropathic pain in some patients.⁶
• Borneol, as a topical application^, shows promise and success in reducing pain.⁷
• Caryophyllene. Researchers combined it with myrcene and ginger extract into hemp seed oil for patients with arthritis to apply. Participants experienced improved pain and joint function with the dietary supplement.⁸

How to Choose Strains for Arthritis

Several factors must be considered when choosing the best strain for arthritis, mainly because everyone is different. Below are some guidelines to help make informed choices.

Focus on Terpenes and Cannabinoids

Terpenes and cannabinoids help determine a strain's effects. For arthritis, strains high in anti-inflammatory terpenes like pinene, myrcene, limonene, camphene, and caryophyllene may be the most beneficial.^3,5-7

Check the Certificate of Analysis (COA)

Always look for a COA when purchasing cannabis. This document outlines a strain's cannabinoid profile and even the terpene profile where required by law. It verifies potency and confirms the strain's purity, helping affirm that the strain or product is free from contaminants like mold or pesticides.

Tailor Selections to Specific Symptoms

For inflammatory pain, consider starting with a CBD-rich strain. It may be a sufficient solution with a lower risk of adverse effects. However, a small dose of THC may be beneficial for some arthritis patients, especially those with difficulty sleeping or nighttime pain. 

Additionally, a balanced 1:1 cannabis product might better help treatment-resistant neuropathic pain. Clinicians might suggest an initial dose of 5–10 mg of CBD, 1–2 times daily.⁹

Learn from Patient Experiences

Because arthritis is a diverse condition, look at past patient experiences for reference. Marijuana for rheumatoid arthritis may not be ideal for gout or other forms of inflammation that patients experience. Some strains may even exacerbate symptoms for certain individuals. 

Patients can make more informed decisions about preferred strains by considering their peers' experiences. Consult with a healthcare professional for personalized guidance to optimize your treatment options.

The 5 Best Strains for Arthritis

Below are five strains arthritis patients find effective. 

Granddaddy Purple

A legendary strain, Grandaddy Purple is also known as Granddaddy Purp or GDP. It is known to have high levels of myrcene, caryophyllene, and pinene, which contribute to its anti-inflammatory and pain-reducing effects.³

With potent relaxing properties, patients report that Granddaddy Purple helps manage pain and promotes restful sleep, making it one of the best strains for arthritis. GDP  is also commonly used for anorexia and anxiety.

White Runtz

Also known as Runtz Weed, White Runtz is often praised for its soothing effects and sweet flavor. It contains terpenes like limonene and myrcene, which are anti-inflammatory and stress-reducing, making them commonly used for muscle spasms, stress, and pain.⁵

It can also be great for daytime use since it promotes relaxation without excessive sedation.

Harlequin

Harlequin is a strain renowned for its high CBD and low THC content. It offers potential therapeutic benefits without THC's intense, intoxicating effects. The strain contains terpenes like myrcene and pinene, which may aid in reducing inflammation and pain.³ 

Patients with rheumatoid arthritis may find Harlequin helpful in easing pain and improving focus and mood. As a high-CBD option, it's often chosen for its clear-headed effects. Consumers report that it provides relief while allowing them to maintain their productivity.

ACDC

ACDC is a high-CBD strain known for its minimal THC content, making it ideal for those seeking relief without a high. 

Its terpene profile includes myrcene, pinene, and caryophyllene, which may work to provide anti-inflammatory and pain-reducing effects.³ ACDC is popular among arthritis patients for its ability to soothe symptoms while promoting relaxation and stress relief.

Pennywise

Pennywise is a balanced strain with an equal ratio of THC to CBD plus a small amount of CBG in some batches. The result is mild intoxicating effects alongside several therapeutic benefits. Terpenes like myrcene, terpinolene, and pinene may contribute further to its calming and anti-inflammatory effects.⁵ Patients report that it helps with both physical pain and mental stress. 

These strains represent some of the best options for arthritis patients. However, everyone is different. Experiment with different strains to find the most effective relief for your symptoms. A range of effects can be tailored to individual needs. Consult with a healthcare professional for personalized guidance.

References

1. Safi K, Sobieraj J, Błaszkiewicz M, Żyła J, Salata B, Dzierżanowski T. Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence. Biomedicines. 2024; 12(2):307. https://doi.org/10.3390/biomedicines12020307 ↩︎
2. Paland N, Hamza H, Pechkovsky A, Aswad M, Shagidov D, Louria-Hayon I. Cannabis and Rheumatoid Arthritis: A Scoping Review Evaluating the Benefits, Risks, and Future Research Directions. Rambam Maimonides Med J. 2023;14(4):e0022. Published 2023 Oct 29. doi:10.5041/RMMJ.10509 ↩︎
3. Baron EP, Lucas P, Eades J, Hogue O. Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. The Journal of headache and pain. 2018;19(1). doi:https://doi.org/10.1186/s10194-018-0862-2 ↩︎
4. Lowin T, Kok C, Smutny S, Pongratz G. Impact of Δ9-Tetrahydrocannabinol on Rheumatoid Arthritis Synovial Fibroblasts Alone and in Co-Culture with Peripheral Blood Mononuclear Cells. Biomedicines. 2022; 10(5):1118. https://doi.org/10.3390/biomedicines10051118 ↩︎
5. Del L, Cortés H, Caballero-Florán IH, et al. Therapeutic Applications of Terpenes on Inflammatory Diseases. Frontiers in pharmacology. 2021;12. doi:https://doi.org/10.3389/fphar.2021.704197 ↩︎
6. Gadotti VM, Huang S, Zamponi GW. The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels. Molecular Brain. 2021;14(1). doi:https://doi.org/10.1186/s13041-021-00876-6 ↩︎
7. Wang S, Zhang D, Jinsheng H, et al. A clinical and mechanistic study of topical borneol‐induced analgesia. Embo Molecular Medicine. 2017;9(6):802-815. doi:https://doi.org/10.15252/emmm.201607300 ↩︎
8. Farì G, Megna M, Scacco S, Ranieri M, Raele MV, Chiaia Noya E, Macchiarola D, Bianchi FP, Carati D, Panico S, et al. Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study. Medicina. 2023; 59(2):191. https://doi.org/10.3390/medicina59020191 ↩︎
9. MacCallum CA, Eadie L, Barr AM, Boivin M, Lu S. Practical Strategies Using Medical Cannabis to Reduce Harms Associated With Long Term Opioid Use in Chronic Pain. Frontiers in Pharmacology. 2021;12. doi:https://doi.org/10.3389/fphar.2021.633168 ↩︎

The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.