Weed for Nausea: What the Latest Research Says

Most people know the feeling: that sudden wave of queasiness that can stop you in your tracks. In fact, more than half of adults deal with at least one bout of nausea each year.¹

Because it’s so common (and sometimes tricky to treat), it’s no surprise that some patients turn to cannabis for relief. But does using weed for nausea really help, or is it mostly hype? In this guide, we look at what the research says so far.

What is Nausea?

Nausea is that uneasy, uncomfortable sensation in the stomach that often comes with the urge to vomit. It’s not a condition in itself, but a symptom of something else happening in the body.

Symptoms of Nausea

Nausea might often come with:

• Sweating or clammy skin.
• Dizziness or lightheadedness.
• Increased saliva or a dry mouth.
• A general feeling of discomfort.
• The urge to vomit, even if you don’t actually throw up.

Causes and Risk Factors for Nausea

Nausea has many possible causes. Sometimes it’s related to short-term issues, like food poisoning. At other times, it’s linked to chronic conditions or treatments. Common causes include:

• Motion sickness.
• Migraines.
• Gastrointestinal disorders.
• Pregnancy.
• Certain medications.
• Chemotherapy or radiation.
• Stress or anxiety.
• Foodborne illnesses.

Some people are also more prone to nausea due to genetics, underlying health conditions, or sensitivity to medications.

How is Nausea Typically Treated?

Nausea treatments depend on the cause of the symptom. In some cases, the feeling fades once the trigger is removed. In others, treatment may involve:

• Prescription medications like antiemetics.
• Natural remedies, including ginger, acupuncture, or peppermint.
• Lifestyle adjustments, like hydration and small, less-seasoned meals.

What Does the Latest Research Say About Using Weed for Nausea?

Cannabis is another option some patients might explore. Some cultures have been using cannabis for nausea (along with other ailments) for centuries.² Today, research is still catching up.

So far, most studies focus on THC, the main intoxicating compound in cannabis. Research highlights its role in reducing nausea in specific medical situations.

The FDA has approved two synthetic THC medications: 

• Dronabinol,
• Nabilone.³

They’re both used for treating chemotherapy-induced nausea and vomiting when other treatments aren’t effective. These are not whole-plant cannabis products, but they do show how THC interacts with the body’s nausea response.

There’s also research on Sativex, a 1:1 blend of THC and CBD approved in Canada and the UK.⁴ In one study, patients who used Sativex alongside traditional anti-nausea medications reported fewer nausea and vomiting symptoms compared to standard treatment alone.

Other cannabinoids are also being studied, though research is still in the early stages. CBDV (cannabidivarin) and CBDA (cannabidiolic acid) have both shown potential for reducing nausea.^5,6 However, this was in animal studies, and there’s not enough data to say how they might work for humans just yet.

What About Risks?

While some research points to potential benefits, cannabis is not risk-free, especially when THC is involved. In studies of THC:CBD extracts, up to one-third of participants experienced side effects, including:

• Moderate to severe sedation, 
• Dizziness,
• Disorientation.⁷

For some people, cannabis can increase feelings of anxiety, panic, or depression.

A rare but serious condition called cannabinoid hyperemesis syndrome (CHS) has also been linked to heavy, long-term cannabis use. CHS causes recurring episodes of nausea, vomiting, and stomach pain that often require medical attention. Scientists are still studying why this happens and who is most at risk.

If you’re considering cannabis for nausea, especially if you’re already taking other medications or supplements, it’s important to check in with your doctor first.

What About CBD and Nausea?

Some studies suggest that CBD and its acid form, CBDA, may help reduce nausea in specific situations, like with chemotherapy-related symptoms.⁸ In fact, CBDA appears to be more potent than CBD in some early research. However, these findings mostly come from animal studies or small-scale trials.

Researchers believe CBD’s interaction with the 5-HT1A receptor, which helps regulate serotonin, may play a role in how it affects nausea.⁹ At this time, results are mixed. Some studies have found that low doses of CBD may reduce nausea, while high doses could actually make it worse. Overall, more research is needed to understand the full picture.

Are There Risks?

CBD is often described as having a low risk profile, but side effects are still possible, especially at higher doses. Some of the most commonly reported issues include:

• Drowsiness.
• Diarrhea.
• Vomiting.
• Changes in liver function.

CBD can also interact with other medications, including those prescribed for nausea. It’s important to talk to your doctor before adding CBD to your routine, especially if you’re already managing other health conditions.

What Does Current Research Say About Terpenes and Nausea Symptoms?

Terpenes are aromatic compounds that help give cannabis its smell and flavor. However, virtually all plants contain terpenes, so they’re not exclusive to cannabis.

Some of these terpenes may also affect how the body responds to nausea. While there’s still a lot to learn, early studies suggest a few terpenes might play a role.

Limonene

Limonene is a citrus-scented terpene found in lemons, oranges, and many cannabis strains. It’s often used in soaps, cleaners, and aromatherapy because of its fresh smell.

In one study, pregnant participants used lemon-scented aromatherapy to help with nausea and vomiting. About 40% of them said it helped.¹⁰ This study didn’t involve cannabis, but it shows why researchers are curious about limonene.

Beta-Caryophyllene

Beta-caryophyllene has a spicy scent, commonly found in spices like black pepper and cloves. It’s also found in certain cannabis strains.

This terpene is unique because it interacts with the CB2 receptors in the body, which are linked to inflammation. In one study, people who took beta-caryophyllene said they felt less nausea compared to those who took a placebo.¹¹

What About Terpene Combinations?

Some people believe that combining different terpenes may have a stronger effect than using just one. This idea is still being studied, but here are some combinations researchers are watching:

• Limonene + Caryophyllene: May help ease nausea and support the body’s natural response to inflammation.
• Limonene + Pinene: Could help with nausea while also keeping you alert.¹²
• Myrcene + Caryophyllene: Might be helpful if nausea comes with pain or stress.
• Linalool + Caryophyllene: May support relaxation when nausea is linked to anxiety.

Currently, most of this research is in its early stages. More studies are needed to know how terpenes work together in cannabis and how they affect nausea in different people.

Best Strains for Nausea According to Patients

Many cannabis consumers share their experiences online and in dispensaries, describing which strains they prefer when they’re feeling queasy or have trouble eating. While scientific studies don’t confirm whether specific strains help with nausea, some patterns show up in patient reviews.

Here are five strains that patients might mention when discussing relief from queasy feelings or loss of appetite. These strains are popular for their terpene profiles, cannabinoid content, and the overall experience they deliver.

1. Motorbreath

Motorbreath is a cross between Chemdawg and an OG Kush variety. Patients often describe it as calming and say it leaves them feeling relaxed yet uplifted.

Motorbreath is rich in limonene, a terpene commonly associated with citrus scents and feelings of refreshment. Some also report that it helps stimulate their appetite, which can be helpful when nausea makes eating difficult.

2. Bubble Gum

Bubble Gum is known for its sweet, berry-like flavor and balanced effects. Patients often choose it for full-body relaxation that comes with a light mental boost.

Its terpene profile typically includes caryophyllene, limonene, and myrcene, along with cannabinoids like THC and CBG. Some say this combination leaves them feeling calmer and more comfortable when nausea strikes.

3. Lemon Haze

Lemon Haze is a favorite for its sharp citrus aroma, complemented by earthy and spicy undertones. It contains limonene, along with CBG and THC, and is often described by patients as mood-lifting and energizing. Many say this combination makes it easier to stay upbeat and eat when they’re feeling unsettled.

4. Girl Scout Cookies (GSC)

Girl Scout Cookies, or GSC, is one of the most talked-about strains in patient communities. It’s a cross between OG Kush and Durban Poison, delivering a sweet and minty flavor with nutty, spicy notes. Patients report that it helps them feel physically relaxed and mentally at ease. Some note that it might even encourage hunger when they’re not feeling their best.

5. Tropicana Cookies

Known as Tropicana Cookies, MTN Trop, or Tropical Cookies F2, this hybrid combines GSC and Tangie genetics. Patients report loving its bright, fruity flavor and terpene mix of limonene, myrcene, caryophyllene, and linalool. Some say it’s a go-to when they’re looking for something that can ease tension while keeping them mentally clear.

Can You Get a Medical Card for Nausea?

In some states, chronic nausea or nausea related to specific medical conditions may qualify patients for a medical cannabis card. However, the rules aren’t the same everywhere. Some states list nausea or vomiting as qualifying conditions, while others don’t.

If you’re considering medical cannabis for nausea, the best first step is to check your state’s current guidelines or speak with a licensed healthcare provider. They can help you understand whether you qualify and what steps to take next.

References

1. Singh P, Yoon SS, Kuo B. Nausea: a review of pathophysiology and therapeutics. Therap Adv Gastroenterol. 2016;9(1):98-112. doi:10.1177/1756283X15618131. ↩︎
2. Parker LA, Rock EM, Limebeer CL. Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol. 2011 Aug;163(7):1411-22. doi: 10.1111/j.1476-5381.2010.01176.x. PMID: 21175589; PMCID: PMC3165951. ↩︎
3. Rock EM, Parker LA. Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting. Frontiers in pharmacology. 2016;7. doi:https://doi.org/10.3389/fphar.2016.00221 ↩︎
4. Rock EM, Sticht MA, Limebeer CL, Parker LA. Cannabinoid Regulation of Acute and Anticipatory Nausea. Cannabis and Cannabinoid Research. 2016;1(1):113-121. doi:https://doi.org/10.1089/can.2016.0006 ↩︎
5. Walsh KB, McKinney AE, Holmes AE. Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses. Frontiers in Pharmacology. 2021;12. doi:https://doi.org/10.3389/fphar.2021.777804 ↩︎
6. Russo EB, Marcu J. Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads. In: Advances in Pharmacology. Vol 80. Elsevier Inc.; 2017:67-134. doi:https://doi.org/10.1016/bs.apha.2017.03.004 ↩︎
7. P. Grimison, A. Mersiades, Kirby A, et al. Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial. Annals of oncology. 2020;31(11):1553-1560. doi:https://doi.org/10.1016/j.annonc.2020.07.020 ↩︎
8. P. Grimison, A. Mersiades, Kirby A, et al. Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial. Annals of oncology. 2020;31(11):1553-1560. doi:https://doi.org/10.1016/j.annonc.2020.07.020 ↩︎
9. Rock EM, Parker LA. Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting. Frontiers in pharmacology. 2016;7. doi:https://doi.org/10.3389/fphar.2016.00221 ↩︎
10. Yavari Kia P, Safajou F, Shahnazi M, Nazemiyeh H. The effect of lemon inhalation aromatherapy on nausea and vomiting of pregnancy: a double-blinded, randomized, controlled clinical trial. Iran Red Crescent Med J. 2014;16(3):e14360. doi:10.5812/ircmj.14360 ↩︎
11. Shim HI, Song DJ, Shin CM, et al. Inhibitory Effects of β-caryophyllene on Helicobacter pylori Infection: A Randomized Double-blind, Placebo-controlled Study. Korean J Gastroenterol. 2019;74(4):199-204. doi:10.4166/kjg.2019.74.4.199 ↩︎
12. Lewis MA, Russo EB, Smith KM. Pharmacological Foundations of Cannabis Chemovars. Planta Medica. 2017;84(04):225-233. doi:10.1055/s-0043-122240 ↩︎

The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.