Ibuprofen is one of the most commonly used over-the-counter pain relievers. They're often taken for headaches, inflammation, or general discomfort. At the same time, cannabis is becoming more popular for similar reasons, with many people turning to it to help manage pain or inflammation.
Because both substances are used for similar symptoms, some may wonder whether it's safe (or even helpful) to take them together. While early research has looked into how ibuprofen and cannabinoids may interact, much of it is still in the early stages.
In this article, we’ll explore what the latest research says about combining cannabis and ibuprofen. Let's take a look at what to keep in mind if you’re considering using both.
What is Ibuprofen?
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) intended to treat inflammatory diseases and rheumatoid disorders. Used in hospitals and also available over the counter, Ibuprofen is the most commonly used NSAID, with roughly 16.5 million prescriptions and over 8.8 million patients in 2020.
Many people use ibuprofen for headaches, cramps, dental pain, fever, pain from an injury, chronic pain, or other inflammatory conditions such as arthritis.
Combining Cannabis and Ibuprofen: What the Latest Research Says
Current research suggests that using cannabis and ibuprofen together does not appear to pose major risks when used responsibly. However, both substances can cause side effects on their own. Ibuprofen may cause side effects such as dizziness, headaches, indigestion, nausea, and vomiting. Likewise, cannabis can also cause side effects, particularly at higher doses. These might include anxiety, drowsiness, coughing, dry mouth, short-term memory loss, and increased appetite.
Some lab research suggests that ibuprofen may raise levels of anandamide, a natural compound in the body that interacts with cannabinoid receptors.1 It’s unclear how this might impact the effects of cannabis, especially THC.
Other studies have shown that certain cannabinoids may interfere with the body's ability to break down ibuprofen by affecting liver enzymes. This may increase ibuprofen levels in the body.2
Some evidence also suggests that ibuprofen might lessen certain effects of THC, like memory impairment. These findings are based on animal studies, so further research in humans is necessary.3
Topical CBD products are sometimes used alongside over-the-counter pain relievers.4 Clinical data on this combination is still limited. While early research is promising, more human studies are needed to better understand the full impact of using ibuprofen and cannabis together.
Are You Considering Using Cannabis and Ibuprofen?
Combining cannabis with any substance or medication carries its own risks. Cannabis research is still in its earliest stages, and there is a lot that researchers still don't know. That leaves the door open for unexpected interactions with other substances. If you are considering combining cannabis with any other substance or medication, speak to your doctor for proper medical guidance.
Likewise, stopping the use of a prescribed medication can lead to unintended consequences. Many medications take time to build up in the body. Stopping suddenly can cause unpleasant and potentially serious or even fatal side effects. If you'd like to stop using or replace a medication, you need to follow the guidance of your medical provider to make any approved adjustments safely.
References
- Paunescu H, Coman OA, Coman L, et al. Cannabinoid system and cyclooxygenases inhibitors. Journal of Medicine and Life. 2011;4(1):11-20.
↩︎ - Doohan PT, Oldfield LD, Arnold JC, Anderson LL. Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization. The AAPS journal. 2021;23(4):91. doi:https://doi.org/10.1208/s12248-021-00616-75.
↩︎ - Chen R, Zhang J, Fan N, et al. Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling. Cell. 2013;155(5):1154-1165. doi:https://doi.org/10.1016/j.cell.2013.10.042
↩︎ - Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018; 23(10):2478. https://doi.org/10.3390/molecules23102478
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The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.
