Advil is a common over-the-counter medication used to reduce pain, fever, and inflammation. Cannabis is also widely used for pain, both under medical supervision and in adult-use settings.
Because both substances can affect how the body processes pain, some people wonder whether it's safe (or helpful) to combine them. While research on this specific interaction is limited, there are some factors to consider before using them together.
This article looks at what science says about combining Advil and cannabis. We'll explore potential risks, how each works in the body, and when to talk to a doctor.
What Is Advil?
Advil is a brand name for a nonsteroidal anti-inflammatory drug (NSAID) called ibuprofen. NSAIDs are a type of medication that works by blocking the production of certain chemicals in the body that cause pain, inflammation, and fever.
Patients commonly use NSAIDs for pain relief, such as headaches, menstrual cramps, toothache, arthritis, and muscle pain. They are also used to reduce fever and swelling and to manage conditions like gout and rheumatoid arthritis.
NSAIDs are widely available over-the-counter and are some of the most commonly used medications in the world. Over 30 million people use NSAIDs every single day. As such, their use makes up 60% of the US over-the-counter analgesic market.
The chemical characteristics of NSAIDs vary, but most work by inhibiting the activity of an enzyme called cyclooxygenase (COX). This enzyme plays a critical role in producing prostaglandins, which are chemical messengers that cause pain and inflammation in the body.1
It’s important to note that while NSAIDs can help manage pain and inflammation, they can also have side effects, especially if taken for a prolonged period or at high doses.
NSAIDs can also interact with other medications, including cannabis, and should be used with care in specific populations, such as the elderly and those with pre-existing medical conditions.
Advil Risks
While Advil can be an effective medication for managing pain and inflammation, it is not without its risks. This is particularly true if taken in excess or combined with other drugs.
Some potential dangers of using Advil include:
Advil Side Effects
The most common side effects include stomach pain, indigestion, nausea, and diarrhea. These symptoms can be problematic for individuals with a history of gastrointestinal issues, such as ulcers or Crohn’s disease.
Besides gastrointestinal issues, Advil can increase the risk of heart attack and stroke, particularly if taken in high doses or over a long period. This risk is particularly pronounced in individuals with a history of heart disease or high blood pressure and in those who are over the age of 60.
Advil can also cause liver and kidney damage, particularly if taken in excess or with other medications that can affect these organs.
Advil’s Potential Interactions with Other Drugs
It’s also important to note that Advil can interact with both prescription and over-the-counter drugs. For example, Advil can increase the risk of bleeding if taken with blood thinners.
It can also interact with certain antidepressants and other medications. Individuals need to speak with their healthcare provider before taking Advil if they are taking other medications to ensure no potential interactions occur.
Advil can also interact with alcohol and certain herbal supplements, such as ginkgo balboa.
Allergic Reactions
Allergic reactions to Advil or other NSAIDs can be severe and life-threatening. People who are allergic to aspirin are more likely to be allergic to NSAIDs, including Advil.
An allergic reaction occurs when the immune system overreacts to a foreign substance, in this case, Advil.
Symptoms of an allergic reaction to Advil can include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. Other symptoms may include abdominal pain, nausea, vomiting, diarrhea, and dizziness. In severe cases, anaphylaxis may occur, a medical emergency that can cause difficulty breathing, a drop in blood pressure, and a loss of consciousness.
If you experience these symptoms after taking Advil or any NSAID, seek medical attention immediately.
When taking Advil or any other medication, it’s essential to always read the label and follow the recommended dosages. If you experience any unwanted side effects or complications while taking Advil, speak with your healthcare provider immediately.
Be sure to inform your healthcare provider of any other medications, supplements, or substances you are taking, including cannabis, to ensure safe and effective treatment.
Combining Advil and Cannabis: What the Latest Research Says
Advil and cannabis are both used to relieve pain and reduce inflammation. While they work through different mechanisms, some may wonder whether combining them could offer stronger relief. Research on this specific combination is limited, but there are some early findings.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by blocking "prostaglandin." These are chemicals in the body that trigger pain and swelling. Cannabis, particularly its cannabinoids and terpenes, also interacts with systems that influence pain and inflammation, including the endocannabinoid system (ECS).
Some research suggests that Advil may slow the breakdown of natural endocannabinoids in the body. Because THC and these endocannabinoids act on the same receptors, there’s speculation that Advil could subtly influence how cannabis feels. However, this is still hypthetical, and human studies are lacking.
Cannabis may interfere with how certain enzymes break down drugs like ibuprofen. One lab study found that cannabis compounds slowed the breakdown of NSAIDs in kidney cells. This could theoretically extend the presence of drugs like Advil in the body. While this hasn't been confirmed in human trials, it highlights the need for caution.
Combining Advil and cannabis could also increase side effects, such as:
- Drowsiness
- Dizziness
- Upset stomach
- Changes in blood pressure or kidney function (especially with long-term use)
Ibuprofen can interact with other medications, like blood thinners or other NSAIDs. This can further increase the risk of bleeding or kidney damage. Always talk to your doctor if you're using other prescriptions or have existing health concerns.
Are You Considering Using Cannabis and Advil?
Combining cannabis with any substance or medication carries its own risks. Cannabis research is still in its earliest stages, and there is a lot that researchers still don't know. That leaves the door open for unexpected interactions with other substances. If you are considering combining cannabis with any other substance or medication, speak to your doctor for proper medical guidance.
Likewise, stopping the use of a prescribed medication can lead to unintended consequences. Many medications take time to build up in the body. Stopping suddenly can cause unpleasant and potentially serious or even fatal side effects. If you'd like to stop using or replace a medication, you need to follow the guidance of your medical provider to make any approved adjustments safely.
Resources
- Ghlichloo I, Gerriets V. Nonsteroidal Anti-inflammatory Drugs (NSAIDs). In: StatPearls [Internet]. StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK547742/ ↩︎
The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.
