Best Cannabinoids for Anxiety

Anxiety is one of the most common conditions that consumers use cannabis to treat. But each cultivar has different cannabinoid concentrations that may benefit various ailments differently. And the extensive selection of cannabis strains available to consumers can feel overwhelming, especially for new patients.

As consumers navigate their dispensary menu, many wonder: what's the preferred combination of cannabinoids for anxiety relief? Everyone responds to cannabis differently, so it's important to try different strains and cannabinoid concentrations to discover the right dosage for your specific needs.

Which Cannabinoids Help Most With Anxiety?

A 2022 clinical review illustrates potential cannabinoids for anxiety relief. In numerous studies across the review, acute doses of CBD (cannabidiol) reduced anxiety in both humans and animals.¹

CBD and THC may both provide anti-anxiety effects. It could be dose-dependent for THC, though, with higher doses actually causing anxiety. However, animal studies still support the potential for low doses of THC to help with anxiety, so microdosing THC might be the way to go.²

CBG (cannabigerol) is another cannabinoid showing promise for anxiety treatment. Recent studies show that CBG may help reduce anxiety at certain lower doses. However, higher doses might trigger anxiety due to its interaction with serotonin receptors.³

A cohort study in the UK reviewed the clinical outcome of anxiety patients treated with medicinal cannabis products. At the six-month mark, 39% of participants were seeing a massive improvement in anxiety. Likewise, 35% of participants improved their sleep score, and 50% improved their quality of life. 

The most common cannabinoids for anxiety were a 0% CBD, 20% THC hybrid flower strain, a full-spectrum 20mg THC oil, and a 50mg CBD broad-spectrum oil.⁴

But what happens if you get anxiety from consuming cannabis? How long does cannabis-induced anxiety last? 

For some, anxiety symptoms pass within 10 minutes of the peak of cannabis' effects. However, others are not so lucky and may experience anxiety or paranoia for anywhere from 45 minutes to 5 hours, depending on your method of consumption and THC dosage.

Ultimately, many patients find cannabis effective for reducing anxiety. Finding the right cannabis for anxiety is the first step. Everyone is different, so it may take some time to discover which strain helps the most.

Which Cannabinoid Concentrations and Ratios Help Most With Anxiety?

Finding the right combination can be crucial for many patient's well-being. Research and anecdotal reports show that a balanced cannabinoid concentration might be the key to finding the ideal dosage. Below are several different ratios that may optimize anti-anxiety effects while minimizing potential side effects in some patients.

CBG

With the rise in minor cannabinoid products across the adult-use, medical, and online hemp markets, more research is discovering the power of cannabinoids like CBG. In particular, CBG has been shown to have anxiety-reducing properties in a recent study from 2024. Researchers found that with just 20mg of CBG, participants had a significant reduction in anxiety and stress without causing impairment.⁵

Microdosing THC

Another strategy for anxiety management gaining popularity is microdosing THC. This is to capitalize on the results from research that low doses of THC can help various symptoms. Likewise, patients can often avoid the risk of greening out with THC doses so small. 

Studies show that microdosing THC might help mitigate anxiety, especially in those sensitive to higher doses of THC. It can help some patients fine-tune their dosage to find the minimum effective dose to provide relief.

Research supports this approach, revealing that low doses of THC can interact with the CB1 receptors in the brain. The interaction might provide anti-anxiety effects, while higher doses might induce it.²

High CBD, Low THC

Other patients may find that low THC isn't enough for their relief. That's where strains high in CBD and low in THC may be more beneficial to them.

CBD is well-documented for its anti-anxiety properties.² When combined with small amounts of THC, it may enhance the therapeutic effect of both. With high CBD and low THC, patients also eliminate the risk of significant anxiety or paranoia that's often associated with higher THC doses.

Products with high CBD and low THC, such as a 20:1 ratio, are growing in popularity among anxiety patients.

How to Choose Strains for Anxiety Based on Cannabinoid Content

Choosing the right strain for anxiety can be challenging, especially with so many strains available. Below are key factors to consider when selecting strains based on cannabinoid content.

Cannabinoid Ratios and Concentrations

Look at the ratios and concentrations of cannabinoids in each strain. A balanced ratio, like 1:1 THC CBD, can provide the benefits of both cannabinoids while helping minimize the intoxicating effects of THC. High CBD and low THC strains are often recommended for new consumers, whereas strains with especially high THC may increase feelings of anxiety in some consumers. 

Some patients find relief from these strains by microdosing THC with them. Finding the right ratio may enhance the entourage effect for a more effective experience.

Certificate of Analysis

Always ask to view the certificate of analysis (COA) for any cannabis product. Lab results reveal detailed information about the strain, including cannabinoid levels and also often the terpene content. The transparency can help one choose products with the right cannabinoid profile blend for anxiety relief.

Likewise, a COA can instill confidence in knowing the strain is accurate and safe for consumption.

Secondary Cannabinoids

CBD and THC are effective in the right ratios, but secondary cannabinoids like CBG can also play a role. Minor cannabinoids, including CBG, may enhance the anti-anxiety effects present in a strain. Look for products or varieties that highlight secondary cannabinoids in their profiles.

Types/Families of Strains

Different families of strains may offer varying effects. For instance, Kush strains are often praised for their relaxing properties, which can be beneficial for anxiety. Users also report Haze and Diesel strains to help with anxiety, though individual experiences can vary. However, the reverse may also be true, so It's essential to experiment with different types to find what works best for you.

Personal Experience and Preferences

Everyone's body chemistry is different, so what works for one person might not work for another. Ultimately, the best weed for anxiety will depend on you. New users may want to start with high CBD strains and gradually explore other options.

Experienced users might find relief with various strains, regardless of terpene content. For example, some individuals might benefit from strains high in pinene, which can have alerting and anti-anxiety effects. Others might prefer strains high in linalool for its potential relaxing properties.

The 5 Best Strains for Anxiety Based on Cannabinoid Content

The best weed for anxiety can vary, as everyone is different. Below are five of the top strains with effective cannabinoids for anxiety.

White Widow

Patients often consume White Widow for appetite stimulation, muscle spasms, headaches, depression, pain, stress, and anxiety. Its pungent and spicy but earthy aroma delivers a creative and social energy. 

For some, White Widow unlocks a more talkative, laid-back session. While it doesn’t contain CBD, it may have a lower THC level and a small amount of CBG. The combination is reported to provide a balance that delivers a calming but energizing perspective.

Harlequin

Harlequin consumers report feeling uplifted, energetic and focused. While it might be too energizing for some, many patients who’ve tried it say it helps with anxiety. Stress and pain are two other symptoms that Harlequin helps to address.

A classic strain, consumers love Harlequin for its flavor and aroma as much as its effects. Harlequin typically has a 2:1 ratio of CBD to THC, but this can vary by harvest; just look at the COA to verify.

Blue Dream

Even beginner consumers find Blue Dream suitable for them. While it often sits between 18 and 24% THC, it doesn’t deliver the same effects as strains with similar ratios. Instead, it may stimulate an uplifted creativity. Its combination of cannabinoids and terpenes can make some feel paranoid, so be sure to start low and go slow with this one. 

The sweet blueberry flavor of Blue Dream is unmistakable. Its earthy pepper undertone helps stimulate the mind, offering symptom relief and relaxation.

ACDC

A CBD-dominant, low-THC variety like ACDC delivers little to no intoxicating effects. It is reported by many to be a great choice for those who need low THC for relief without the high. Patients report using the strain for various ailments, including pain, epilepsy, and anxiety. 

While ACDC makes some users feel focused and uplifted, it can also stimulate deep relaxation. Thus, it’s a happy medium for CBD-dominant hybrid fans.

Girl Scout Cookies (GSC)

Girl Scout Cookies is another famous cultivar with a legendary reputation. Body relaxation, euphoria, sociability, and energy are all common effects for patients who use GSC. The blend might be why patients use it to treat symptoms of nausea, headaches, appetite, stress, pain, and anxiety.

References

1. Peng J, Fan M, An C, Ni F, Huang W, Luo J. A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD). Basic & Clinical Pharmacology & Toxicology. 2022;130(4):439-456. doi:https://doi.org/10.1111/bcpt.13710 ↩︎
2. Sharpe L, Sinclair J, Kramer A, de Manincor M, Sarris J. Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties. J Transl Med. 2020;18(1):374. Published 2020 Oct 2. doi:10.1186/s12967-020-02518-2 ↩︎
3. Russo EB, Cuttler C, Cooper ZD, Stueber A, Whiteley VL, Sexton M. Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms. Cannabis Cannabinoid Res. 2022;7(5):706-716. doi:10.1089/can.2021.0058 ↩︎
4. Rifkin-Zybutz R, Erridge S, Holvey C, et al. Clinical outcome data of anxiety patients treated with cannabis-based medicinal products in the United Kingdom: a cohort study from the UK Medical Cannabis Registry. Psychopharmacology. 2023;240(8):1735-1745. doi:https://doi.org/10.1007/s00213-023-06399-3 ↩︎
5. Cuttler C, Stueber A, Cooper ZD, Russo E. Acute effects of cannabigerol on anxiety, stress, and mood: a double-blind, placebo-controlled, crossover, field trial. Scientific Reports. 2024;14(1). doi:https://doi.org/10.1038/s41598-024-66879-0 ↩︎

The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.