Cannabis for MS: The Best Cannabinoids

By Halla Mannering Published April 25th

Fact-checked by Deb Tharp

When it comes to using cannabis for MS (multiple sclerosis), it’s a balance between finding the right cannabinoid concentration for your symptoms and a consumption method that suits your comfort level.

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Which Cannabinoids Help Most With MS?

Cannabinoids are compounds produced by the cannabis plant. Different cannabinoids can bring about various benefits and effects.

Research has found that cannabinoid-based therapy may limit some symptoms of MS. This is likely due to the way that cannabinoids interact with CB1 receptors and restrict certain chemicals in the brain. This interaction may help alleviate pain, spasticity, and inflammation, improving the quality of life for those with multiple sclerosis.

Some patients using cannabis for MS report that products with both CBD and THC help with pain related to the condition.

While there are many other cannabinoids besides just CBD and THC, there is limited research into these options. If you’re unsure which cannabinoids are right for your symptoms, consider speaking with a doctor.

Which Cannabinoid Concentrations and Ratios Help Most With MS?

Top cannabinoid ratios when using cannabis for MS.

One of the most common ratios used for MS symptoms is a 1:1 ratio of THC to CBD. Many people find this ratio helpful in relieving pain and enhancing relaxation. It is important to note that this ratio may have intoxicating effects.1

How to Choose Strains for MS Based on Cannabinoid Content

There are several factors to consider when picking the best strain for MS. Cannabis flower is either high in THC or high in CBD. Both can have beneficial effects, and they typically contain other cannabinoids and terpenes to enhance their effects.

High-THC strains will cause intoxicating effects, which some consumers might choose to avoid. In this case, a high CBD cultivar may be better suited.

The best way to find which cultivars are right for your MS symptoms is to note how different ones affect you and be open to trying a few other options. Consider starting with a 1:1 THC and CBD product to see how your body responds.

The 5 Best Strains for MS Based on Cannabinoid Content

5 Best strains for MS

There are a few different cultivars to consider for MS. While they may not all be available at your local dispensary, they can be guidelines for what to look for.

Frank’s Gift: This is a phenotype of Skunk Haze. Frank's Gift is very high in CBD, with some cultivars clocking in at 20%, and THC ranging from 1% to 8%. In general, CBD will rang from 10% to 20% at a 3:1 CBD to THC ratio. This cultivar’s cannabinoid ratio may make it suitable for managing pain and inflammation with very little intoxication. 

CBD Shark: Users report this strain helps them withMany patients report it helps them feel relaxed and focused. Additionally, with a slightly higher than 1:1 ratio of CBD to THC, , it minimizes intoxicating effects, making it a suitable option for those seeking relief with less impairment. Still, with some buds containing as much as 15% THC,  it will likely cause a high.

Harlequin: This cultivar is a CBD-rich patient favorite. Boasting a 2:1 CBD to THC ratio, it can also help with relaxation without overwhelming feelings of intoxication. 

Pennywise: This cultivar is known for having a 1:1 CBD to THC ratiot , offering balanced effects from both compounds. Its balanced ratio makes it popular among MS patients. Be aware it can still cause a high. In fact, it's rumored to be named after the killer clown because of its "killer high."

Critical Mass: Critical mass also has a 1:1 CBD to THC ratio, but at very low potency. Some buds contain as little as 5% THC with others up to 10%. Anecdotal reports from fans say this strain helps them feel relaxed and sleepy with a much more subtle high, making it ideal for novice users or those with low tolerance.

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References

  1. Breijyeh Z., Jubeh B., Bufo S., Karaman R., Scrano L. Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins. 2021;13:117. doi: 10.3390/toxins13020117.  https://pmc.ncbi.nlm.nih.gov/articles/PMC9148011/ ↩︎

The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.

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