Cannabis for Migraines: The Best Cannabinoids

With so many different cannabis strains and cannabinoid concentrations available to patients today, it can be confusing for new patients to figure out the right product options. 

Many patients report that using cannabis for migraines has been effective when seeking relief. Finding the right cannabinoids for migraines can be challenging at first, but learning how to locate the right strain and concentration may improve a patient's life significantly.  

Which Cannabinoids Help Most With Migraines?

Cannabinoids are compounds that are naturally found in cannabis. These compounds interact with the body and bring about certain effects, so it’s important to be aware of the ways that patients can use cannabis for migraines.

Some cannabinoids, like CBD, are specifically recommended for those who struggle with migraines as they can interact with the body’s pain receptors, potentially providing significant relief for many users. A study was conducted on rats to examine how effective CBD can be at treating migraine pain. This study did show promising results but pointed to the fact that there’s a significant need for more research to be done in this area.¹

Some minor cannabinoids that have specifically been found to help migraines include THCA, THCV, CBDA, CBG, CBC, and CBN.² Exploring these cannabinoids on their own can be beneficial, but trying products that combine them may also be helpful. By combining certain cannabinoids, patients can be sure they’re getting the full spectrum of potential benefits and positive effects they’re looking for.

Cannabinoids work in the body in various ways, and some people find them more helpful than others. Some patients may find that cannabinoids help them completely wean off other pain medications, while others may notice that cannabis isn’t strong enough to help with their pain to the extent that they’re looking for.

When it comes to using cannabis for migraines, there are so many different factors to consider. Some people report that they get a headache from cannabis use. If you’re one of those people, then it’s probably best to speak with your doctor about other ways that you can get migraine relief. The past can be a good predictor of the future when it comes to cannabis use, so it’s best to play it safe if you’ve had negative previous experiences.

Which Cannabinoid Concentrations and Ratios Help Most With Migraines?

There are many different cannabinoid concentrations and ratios available. Understanding the different options is important to know when selecting cannabis for migraines.

Cannabinoids on their own can be powerful, but they may be much more powerful when they’re paired together. By finding the right combination, patients may get greater relief and hopefully achieve their desired results.

Research has found that strains that are high in CBD may be effective for treating pain, including migraine pain.³ While THC and CBD alone for migraines may be effective, patients may have more luck with a combination of both THC and CBD.⁴ Another great potential benefit of CBD is that it often has fewer unwanted side effects, so it may be a good option for patients new to using cannabis.

How to Choose Strains for Migraines Based on Cannabinoid Content

Many users suggest Kush or Haze cultivars for migraine relief. However, what works for one person may not work for another. Patients should try a few options to narrow their choices and find the best strain.

Strains that combine both THC and CBD are likely to be the most effective at treating migraine pain. When combining these cannabinoids,  patients may experience the entourage effect and other benefits than using THC or CBD on their own.

There are a variety of different ratios available when it comes to products that combine both THC and CBD. The proper ratio will depend on a variety of factors. Patients looking for the traditional high that cannabis is associated with should choose a ratio with higher amounts of THC. However, a strain with higher amounts of CBD may be a good option for patients who need to remain more level-headed throughout their day.  

A certificate of analysis is one of the most important things to look for when shopping for a product. Products with COAs are safe to use and have undergone the necessary lab testing. If a product hasn’t been tested, consumers don’t know what the cannabinoid level is or what contaminants could be in it. Because of this, it’s best to shop at reputable dispensaries that only sell certified lab-tested products.

As much as selecting the right strain and cannabinoids is important, there are other factors to consider as well. Thinking about dosage is essential, as the dosage taken is one of the biggest influences on the cannabis use experience.

If you’re new to using cannabis, a good rule of thumb is that you should start with a small dosage. Once you feel comfortable with that dosage, you can continue taking the same amount or gradually increase the dosage if you think that you need more to get relief.

The 5 Best Strains for Migraines Based on Cannabinoid Content

Using THC for migraines may be effective, but it’s important to be selective about the strains you’re using. Below are some top strains to consider if you’re looking for migraine relief.

1. Mimosa: This is a THC-dominant strain with 20% THC and, in some batches, around 1% CBG. Mimosa is a powerful option with high levels of caryophyllene. Many people report that this strain helps them feel relaxed, which may be helpful when dealing with a migraine.
2. Trainwreck: Trainwreck has 18% THC and about 1% CBG on average. Many people report that this strain makes them feel creative and motivated, so it may be a good choice for patients looking for other benefits in addition to migraine relief. Many people find that the THC levels in this strain are very helpful in treating pain.
3. Gary Payton: This strain contains 25% THC and is known by consumers for its ability to treat migraines. Some terpenes included in this strain are limonene and pinene. This strain may have various benefits, so it may be a great choice if you’re searching for a comprehensive option. 
4. Cherry Pie:  Cherry Pie is a strain with moderate THC levels and is commonly used for pain by cannabis users. 
5. Chemdawg: This strain is said to be more energizing than calming, which may be helpful for those dealing with pain. Myrcene and limonene are two of the top terpenes found in Chemdawg. This strain is reported to make you sleepy and potentially relieve migraines.

References

1. Greco R, Francavilla M, Demartini C, et al. Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine. The Journal of Headache and Pain. 2023;24(1). doi:https://doi.org/10.1186/s10194-023-01589-y ↩︎
2. Baron EP. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Headache: The Journal of Head and Face Pain. 2018;58(7):1139-1186. doi:https://doi.org/10.1111/head.13345 ↩︎
3. MacCallum CA, Eadie L, Barr AM, Boivin M, Lu S. Practical Strategies Using Medical Cannabis to Reduce Harms Associated With Long Term Opioid Use in Chronic Pain. Frontiers in Pharmacology. 2021;12. doi:https://doi.org/10.3389/fphar.2021.633168 ↩︎
4. Mlost J, Bryk M, Starowicz K. Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action. International Journal of Molecular Sciences. 2020; 21(22):8870. https://doi.org/10.3390/ijms21228870 ↩︎

The information in this article and any included images or charts are for educational purposes only. This information is neither a substitute for, nor does it replace, professional legal advice or medical advice, diagnosis, or treatment. If you have any concerns or questions about laws, regulations, or your health, you should always consult with an attorney, physician or other licensed professional.